Abstract：
Objective To isolate and purify antibiotics from the metabolites of streptomyces I06A-00625 (cpcc201504), and determine its structure and activity.
Methods Macroporous resin X-5, Sephadex LH-20 and HPLC were used to isolate and purify compounds with antifungal activity. Structures of the compounds were determined by UV, HR-MS and NMR spectral data. Their antifungal activity was also studied.
Results Total six compounds were finally obtained, including I06A625A, 206A, 206B and three tetraene macrolide antibiotics, Tetramycin A, Tetramycin B and Tetrin A. Among them, 206A was first isolated from natural product as reported. Activity study showed that I06A625A had anti-aeruginous Pseudomonas activity, and three tetraene macrolide antibiotics had anti-fungal activity.
Conclusions Streptomyces I06A-00625 could produce a variety of active compounds including nucleoside with the anti-aeruginous Pseudomonas activity and tetraene macrolide antibiotics with anti-fungal activity.
2012, Vol. 7 
